OR 1.53
Clinical pregnancy rate in ART associated with good sleep quality.
Meta-analysis of 8 studies, n = 6,754. Archives of Gynecology and Obstetrics, 2025. 95% CI 1.16–2.03.
Founding cohort 2026 · pilots open
Better-prepared patients. Higher live birth rates.
Authored by Dr Vasileios Sarafis MD — UK-trained Consultant Obstetrician, Gynaecologist and Fertility Specialist. The S.A.F.A.R.I. framework is the subject of a narrative review currently in preparation.
Safari is a 90-day, clinically-authored fertility preparation protocol that translates the published evidence on sleep, nutrition, mitochondrial support, and environmental exposures into one protocol your patients actually follow.
i.
The 90 days no guideline addresses.
Per-cycle live birth rates remain below 40% in even the most favourable prognostic groups. Approximately 25–30% of infertile couples receive a diagnosis of unexplained infertility — a label that reflects inconsistent diagnostic criteria more than absent pathology.
Meanwhile, four decades of evidence implicates modifiable preconception factors — sleep, nutrition, micronutrient status, environmental exposures, stress regulation — in gamete quality, endometrial receptivity, and treatment outcomes. The mechanistic pathways are well characterised.
Yet no major fertility society — ESHRE, ASRM, NICE, or WHO — currently recommends a structured, multimodal preconception optimisation programme.
The clinical evidence is there. The translation into clinical practice is not.
ii.
The published numbers Safari is built on.
2.7×
IVF live birth rate in the highest-adherence Mediterranean diet tertile, women under 35.
Karayiannis et al., Human Reproduction, 2018. n = 244 non-obese IVF patients, Greece.
OR 1.67
Clinical pregnancy rate with CoQ10 supplementation. Strongest signal in DOR and PCOS.
Florou et al., 2024. Meta-analysis of 9 RCTs, n = 1,028 women. 95% CI 1.26–2.22.
+15pp
Cumulative success advantage of treatment completers vs. all starters (57.9% vs. 42.7%).
Gameiro et al., 2012. 22 studies, n = 21,453 patients.
58%
Reclassification rate of "unexplained infertility" with full diagnostic workup, including laparoscopy.
Van Gestel et al., 2024. Systematic review, 11 studies, n = 1,707 patients.
The integrated S.A.F.A.R.I. Protocol has not been prospectively evaluated; component-level evidence varies in strength. A pragmatic registry study and a stepped-wedge cluster-randomised trial are proposed in the manuscript as the next research steps.
iii.
Three reasons cycles succeed with Safari patients.
No. 1
Better gametes by design.
The 90-day window of oocyte maturation and the 74 days of spermatogenesis are the period in which lifestyle, nutritional, and environmental inputs plausibly influence the quality of the gametes a patient brings to your cycle.
Safari structures that window — six domains, three phases, daily anchors — into a protocol patients can actually follow rather than guess at. Couples-based by design. The male partner starts on day one; sperm quality is treated with the same structural attention as oocyte quality.
No. 2
A protocol patients complete.
The published preconception literature is scattered across decades, journals, and specialties. Patients reading it on their own do not finish it.
Safari operationalises it: structured daily habits, phase-gated content, behavioural anchoring, partner accountability. Engineered for adherence — not just information. The clinical effect is that patients arrive at your cycles having actually executed a preparation programme.
No. 3
Lower dropout. More cycles per patient.
36% of ART patients discontinue treatment, primarily from emotional burden rather than clinical failure. The single largest preventable barrier to cumulative live birth is the patient walking away.
Safari is built against the dropout pattern — structured scaffolding through the two-week wait, designed regression-prevention after a negative result, between-cycle re-anchoring. The patient who completes a third cycle is the patient who could have stopped after the first.
Shen et al., 2026. 62 studies, n = 330,593 patients.
iv.
What patients experience.
Your Safari route
4%
Your Safari Route
FOUNDATION
Day 4 / 90
Six Points · Tended0 / 6
Sleep
TAP
Protein AM
TAP
Supplements
TAP
Hydration
TAP
Stress care
TAP
Toxin swap
TAP
Daily wisdom
Connection regulates your nervous system. Isolation amplifies stress.
— The Egg & Sperm Quality Plan
JOURNEY
VAULT
BREATHE
GUIDE
Six daily anchors
Mapped to S.A.F.A.R.I.
The 12-week roadmap
4%
1
WEEK 1 · D 1–7
Settling in
WEEK 2 · D 8–14
First rhythm
WEEK 3 · D 15–21
Sleep stabilises
2
3
JOURNEY
VAULT
BREATHE
GUIDE
Three phases, twelve weeks
Layered, not stacked.
Breathing Sherpa
Ready
Tap play to begin
4–7–8 Breathing
Inhale 4s · Hold 7s · Exhale 8s
JOURNEY
VAULT
BREATHE
GUIDE
Resilience for the two-week wait
A breath, always one tap away.
v.
The textbook behind the protocol.
The Egg & Sperm Quality Plan
The long-form clinical reference for the S.A.F.A.R.I. Protocol. Written by Dr Vasileios Sarafis MD. Covers IVF, ICSI, IUI, and surgical considerations alongside the protocol's six domains, the underlying evidence, and a day-by-day implementation guide.
Sixteen chapters. The full evidence synthesis. Read by patients, useful to clinicians.
vi.
What changes when Safari is part of your patient pathway.
Higher cumulative live birth rate per patient acquired.
Better-prepared gametes plus lower mid-journey dropout means more of the cycles you book end in a live birth.
Differentiation no competitor can match.
Yours becomes the clinic that offers a structured, evidence-based preparation protocol authored by a practising fertility specialist. No fertility app, supplement brand, or content platform offers that.
A patient acquisition story.
Your marketing team gains something to talk about that isn't success-rate numerology. "Our clinic uses Safari" is a sentence patients searching for an edge respond to.
A retention story.
Patients who complete the 90-day protocol are emotionally invested in the journey before stimulation begins. They are also the patients who return for a second and third cycle if needed.
Fewer cancelled cycles.
Patients who arrive better prepared — sleep regulated, supplementation coordinated, baseline labs corrected — have fewer mid-cycle complications and fewer cancelled retrievals.
Zero workflow burden.
Safari operates patient-side. No system integration, no nurse training, no new admin. Implementation is a code at booking.
vii.
One protocol, every phase of the journey.
| Where your patient is | What Safari is doing |
|---|---|
| On a waiting list, or between cycles | Full protocol — Foundation, Precision Targeting, Resilience. |
| Active stimulation | Light mode — supplement coordination, sleep regulation, breathing. |
| Retrieval and transfer | Stress regulation, sleep support, simple meals. |
| Two-week wait | Resilience mode — designed against post-transfer panic. |
| After a negative result | Re-anchoring — designed against dropout. |
Safari adapts to your patient's timeline. It does not impose its own.
viii.
Three ways to bring Safari to your clinic.
Recommend.
Free · No commitment
Add Safari to your patient welcome materials, your waiting-list communications, and your post-consult handouts. Patients access on standard consumer terms. Your clinic appears as a recommending source — implicit endorsement, zero administrative cost.
Bulk activation codes.
Volume pricing
Volume pricing on Book Owner Codes from a set minimum order. Hand patients a code at booking; they unlock the full protocol, the Safari Toolkit, and the book. Optional clinic-branded welcome flow.
Founding cohort.
2026 · Limited intake
Founding partner conversations open in Q3 2026. Limited intake; expressions of interest welcomed. A small cohort of clinics will partner directly with Dr Sarafis on integration into their specific patient mix — IVF, ICSI, IUI, or surgical preparation — with quarterly outcomes review and anonymised network learnings.
ix.
Before you ask.
What outcomes can we expect?
The component evidence is published and graded; selected signals are above. The integrated protocol has not been prospectively evaluated, and we are explicit about that.
The plausible mechanism — better-quality gametes plus higher adherence plus lower dropout — points to higher cumulative live birth rates per patient acquired. The founding-cohort programme is designed to begin generating the prospective evidence.
How is Safari different from a patient downloading any fertility app?
Safari is authored by Dr Vasileios Sarafis, a practising UK-trained fertility specialist, and built on a documented evidence base across six domains. Every other product in this space is content marketing or consumer wellness with no clinical authorship.
What does this mean for our clinic's brand?
The clinic that offers Safari positions itself as the clinic doing more — measurable preparation rather than supplement advice and forum links. The protocol's evidence base and clinical authorship give your patient acquisition team a credible, defensible story.
Does it integrate with our workflow?
Safari operates entirely patient-side. No system integration, no nurse training, no new admin.
The protocol is engineered to coordinate around your clinical decisions rather than compete with them — supplementation pauses around procedures, exercise restrictions defer to your guidance, treatment-day modifications follow your instructions.
How is patient data handled?
GDPR-compliant, EU data residency. Patients own their data and consent explicitly to anything shared with their clinic. Nothing is shared without consent.
Who is behind the protocol?
Dr Vasileios Sarafis MD — UK-trained Consultant Obstetrician, Gynaecologist, and Fertility Specialist. Trained at C.Re.A.Te Fertility (London) under Prof. Geeta Nargund and Prof. Stuart Campbell. Author of The Egg & Sperm Quality Plan and creator of the S.A.F.A.R.I. Protocol.
x.
Bring Safari to your next intake cohort.
Write directly. No automation, no follow-up sequences. Personally reviewed by our clinical partnerships lead — if it's not a fit, we'll say so in the first reply.
info@thesafarihealth.com · we reply within one working day.